Florentis
Exploring Microbiota–Metabolism Research
In-depth investigations into the evidence base linking gut microbiota composition to physiological regulation and metabolic processes
Understanding the Evidence Base
The following articles provide detailed exploration of mechanisms, research findings, and the current state of evidence linking gut microbiota composition to metabolic regulation and body weight dynamics. Each article contextualises specific research findings within broader understanding of the gut–metabolism axis.
These materials are presented as educational content for understanding physiological science, without personal recommendations or outcome promises. The diversity of research methodologies, study populations, and analytical approaches contributes to variable findings across the literature—a complexity reflected in these articles.
Research Topics
Short-Chain Fatty Acids and Their Metabolic Signalling Roles
Comprehensive examination of SCFA production pathways, absorption mechanisms, distribution across tissues, and signalling actions on appetite hormones and metabolic regulation.
Read the article →Gut Microbiota Composition in Lean vs Obese Individuals
Comparative analysis of observational research documenting differences in bacterial diversity, phylogenetic markers, and community composition across body weight categories.
Read the article →Gut Permeability and Metabolic Endotoxemia
Detailed investigation of intestinal barrier dysfunction, bacterial lipopolysaccharide translocation, and inflammatory cascades linking dysbiosis to metabolic disease.
Read the article →Dietary Substrates Shaping Microbial Diversity
Analysis of dietary fibre types, polyphenolic compounds, and macronutrient composition as ecological drivers of microbial community assembly and metabolic capacity.
Read the article →Gut–Brain Communication in Energy Homeostasis
Overview of neural, endocrine, and immune signalling pathways through which microbiota-derived signals regulate central appetite centres and energy metabolism.
Read the article →Longitudinal Studies on Microbiota and Body Weight Changes
Summary of prospective investigations tracking microbial dynamics during weight loss, weight gain, and response to dietary or surgical interventions.
Read the article →Return to the main resource for an overview of key mechanisms and evidence.
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